"Dual acting cancer therapeutics targeting
SOLID Therapeutics is an early-stage oncology company which is based on research at University of Copenhagen joining expertise in metabolite GPCR structure-based drug discovery in the Schwartz-Frimurer labs at the Novo Nordisk Foundation (NNF) Center for Basic Metabolic Research (CBMR) with the deep insight into cell biology of the tumor microenvironment in the Falsig Petersen lab. The concept of HCAR1 antagonists as anti-cancer drugs was supported by an Exploratory Pre-Seed grant from NNF, a Pre-Seed grant from the Bioinnovation Institute (BII) and an Innobooster grant from Innovationsfonden. The company was officially founded in March 2022 when accepted into the Venture Lab at BII.
"WE AIM TO DELIVER NOVEL CANCER THERAPEUTICS
WITH DUAL MODE OF ACTION TARGETING
BOTH CANCER CELLS AND IMMUNE CELLS"
ONE target - TWO mechanisms
A hallmark of solid tumors is the hypoxic and acidic microenvironment rich in lactate, which today is known to act as a signaling molecule sensed by the HCAR1/GPR81 receptor. HCAR1 expression is normally highly tissue restricted but is strongly induced by the tumor microenvironment in basically all types of solid tumors including hard-to-treat cancers. Importantly, high HCAR1 expression is associated with poor survival in e.g., breast and pancreatic cancer patients.
HCAR1 is expressed both on cancer cells and anti-cancer immune cells. HCAR1 improves survival of cancer cells by reprogramming their metabolism and upregulating defense mechanisms such as angiogenesis and check-point ligands. Importantly, HCAR1 is also involved directly in immune evasion by decreasing immune cell activation.
HCAR1 antagonists will therefore attack solid tumors in two ways by both directly impairing cancer cell survival and by stimulating tumor immunity.
Lundø et al. Cell Metabol. (2020) 31(4):666-668.
Figure created with BioRender.com
SOLID named one of "10 Danish Startups to Watch" by Sifted
SOLID was named as one of "10 Danish Startups to Watch" by Sifted.
The list was put together with investors from Climentum Capital, byFounders and Novo Holdings.
Read the full article here: Sifted Article
SOLID Tx accepted into BII Venture House program
We are thrilled to announce that we have been accepted into the prestigious Venture House program at BioInnovation Institute!
Read the announcement here: BII announcement
Read the MedWatch article here: MedWatch article
SOLID at BioInnovation Institutes DemoDay 2023
BioInnovation Institute hosted its recurring event DemoDay! Our CEO Mette gave a "graduation" pitch highlighting all the fantastic progress the Venture Lab program has enabled us to make.
Ole Maaløes Vej 3, 1 floor
DK 2200 Copenhagen N